Silicone

The all-rounder of caulk. This all-purpose type is a go-to choice for sealing bathtubs, sinks, windows and toilets, and it usually dries clear. It is the most resistant to mold and mildew but it can’t be painted, so keep that in mind!

Acrylic latex

The most beginner-friendly caulk, this type is easy to work with, can be painted over, and works best for filling gaps in molding and trim. This type of caulk is sometimes also called latex caulk, and is best to use with drywall, wood and masonry.

Polyurethane 

The heavy duty cousin of acrylic, polyurethane caulk is typically used in projects that really need to test durability like outdoor concrete and masonry projects. This type of caulk can be painted over. 

Hybrid

Typically the most expensive caulk because it marries both flexibility and durability, it can be used both indoors and outdoors and has the best adhesion of all the types. This type of caulk can be used almost anywhere other caulks are used.